IGF1-LR3

CAS 946870-92-4 · Endocrine Research

1 MG

$69.00

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⚠ RESEARCH USE ONLY

This product is sold strictly for in vitro laboratory research use only. Not for human or animal consumption, diagnostic use, or therapeutic application. Purchasers must be qualified researchers or authorized purchasers for a research institution.

CERTIFICATE OF ANALYSIS

Third party tested for: Purity · ID · Quantity

BATCH #202610071512 View All →

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IGF1-LR3 Overview

IGF1-LR3 (Long R3 insulin-like growth factor-I) is an 83-amino-acid synthetic analog of human IGF-1. It carries a glutamic acid-to-arginine substitution at position 3 and a 13-amino-acid N-terminal extension, modifications that sharply reduce binding to IGF-binding proteins (IGFBPs).

In research models, IGF1-LR3 has been examined for IGF-1 receptor signaling, cell proliferation and survival pathways, myoblast differentiation, and as a potent growth supplement in serum-free cell culture systems.

Reference: Tomas F. M. et al. (1996), J Endocrinol, 150(1), 77-84.

History

Native IGF-1 was first described in the 1950s as a serum “sulfation factor” and later characterized as somatomedin C, with its amino-acid sequence determined in 1978. Because IGFBPs limit the activity of native IGF-1 in culture, analogs with reduced IGFBP affinity were developed. The Long R3 variant was engineered in the early 1990s and became widely used in biopharmaceutical cell culture and growth-factor signaling research.

Reference: Garnaut S. M. et al. (2002), Growth Factors, 20(1), 17-25.

IGF1-LR3 Structure

CAS #: 946870-92-4

Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

Molecular Weight: ~9,111 g/mol

Research Findings

IGF1-LR3 has primarily been studied in cell culture and preclinical models. Published work centers on activation of the IGF-1 receptor and its downstream PI3K/Akt and MAPK/ERK pathways, and on how reduced IGFBP binding changes potency relative to native IGF-1.

Key Areas of Research:

Receptor signaling: IGF-1R activation and downstream PI3K/Akt and MAPK/ERK cascades
Cell proliferation: Growth and survival effects in cultured cell lines
Muscle cell biology: Myoblast proliferation and differentiation in vitro
Cell culture: Use as a serum-free media supplement for biopharmaceutical production

These characteristics make IGF1-LR3 a widely used research tool for studying growth-factor signaling and IGFBP biology.

References: Garnaut S. M. et al. (2002), Growth Factors, 20(1), 17-25.; Tomas F. M. et al. (1996), J Endocrinol, 150(1), 77-84.

References

Frequently Asked Questions

Everything you need to know about our products and processes.

Each vial contains the exact quantity listed on the label. A 1 mg vial contains 1 mg of lyophilized peptide. Research-grade purity supports accurate dosing for experimental protocols.

Peptides ship as lyophilized powder. Every order includes a complimentary vial of bacteriostatic water for reconstitution. Any additional supplies (syringes, mixing vials, etc.) must be sourced separately by the research institution.

Sealed lyophilized peptide remains stable for approximately 2 years when stored properly. After reconstitution, the solution should be refrigerated and typically retains stability for several weeks depending on temperature and handling conditions.

No. Our products are supplied strictly for in vitro laboratory research. Because these compounds are not authorized for use on humans or animals outside approved research settings, we do not provide usage or dosing instructions.

All peptides are guaranteed to be at least 98% pure, verified by HPLC and mass spectrometry. A Certificate of Analysis is available for every batch.

Keep lyophilized peptides in a cool, dry place away from direct heat and light. Once reconstituted, refrigerate the solution to maintain stability and preserve peptide integrity.