MOTS-c

CAS 1627580-64-6 · Cellular Research

10 MG

$45.00

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⚠ RESEARCH USE ONLY

This product is sold strictly for in vitro laboratory research use only. Not for human or animal consumption, diagnostic use, or therapeutic application. Purchasers must be qualified researchers or authorized purchasers for a research institution.

CERTIFICATE OF ANALYSIS

Third party tested for: Purity · ID · Quantity

BATCH #26070305030
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MOTS-c Overview

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino-acid peptide encoded within the mitochondrial genome. It represents one of the first identified mitochondrial-derived peptides and is studied for its role in cellular metabolic regulation, AMPK pathway activation, and mitochondrial-nuclear signaling communication.

In research models, MOTS-c has been examined for its effects on glucose metabolism, insulin sensitivity, exercise-mimetic pathways, and age-related metabolic decline.

Reference: Lee C. et al. (2015), Cell Metabolism, 21(3), 443-454.

History

MOTS-c was first identified in 2015 by Lee and colleagues at the University of Southern California, marking a significant discovery in mitochondrial biology. The peptide is encoded by a small open reading frame within the mitochondrial 12S ribosomal RNA gene, challenging the long-held view that mitochondrial DNA encoded only 13 proteins. Its discovery opened a new field of research into mitochondrial-derived peptides and their roles as retrograde signaling molecules between mitochondria and the nucleus.

Reference: Kim S. J. et al. (2018), Free Radical Biology and Medicine, 129, 526-541.

MOTS-c Structure

CAS #: 1627580-64-6

Molecular Formula: C₇₈H₁₃₃N₂₃O₂₂S₂

Molecular Weight: 1,820.16 g/mol

PubChem CID: 121303862

Research Findings

MOTS-c has been examined across metabolic, muscular, and mitochondrial research models. Reported findings describe activation of the AMPK signaling pathway, enhancement of glucose uptake in skeletal muscle models, improvements in insulin sensitivity in aged mouse models, and translocation to the nucleus under metabolic stress where it modulates nuclear gene expression.

Key Areas of Research:

Metabolic signaling: AMPK activation and glucose homeostasis
Mitochondrial-nuclear crosstalk: Retrograde signaling and gene regulation
Exercise physiology: Physical performance and endurance capacity models
Aging biology: Age-related metabolic decline and cellular homeostasis

These observations position MOTS-c as a widely-used research tool for studying mitochondrial-derived signaling and metabolic regulation in preclinical models.

References: Reynolds J. C. et al. (2021), Nature Communications, 12, 470; Kim K. H. et al. (2018), Cell Metabolism, 28(3), 516-524.

References

Lee C. et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metabolism, 21(3), 443-454.
Kim S. J. et al. (2018). The mitochondrial-encoded peptide MOTS-c translocates to the nucleus. Free Radical Biology and Medicine, 129, 526-541.
Reynolds J. C. et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline. Nature Communications, 12, 470.
Kim K. H. et al. (2018). MOTS-c: an equal opportunity insulin sensitizer. Cell Metabolism, 28(3), 516-524.
Yin X. et al. (2020). MOTS-c and aging-related metabolic disease. Aging and Disease, 11(4), 1010-1019.

Frequently Asked Questions

Everything you need to know about our products and processes.

Each vial contains the exact quantity listed on the label. A 10 mg vial contains 10 mg of lyophilized peptide. Research-grade purity supports accurate dosing for experimental protocols.

Peptides ship as lyophilized powder. Every order includes a complimentary vial of bacteriostatic water for reconstitution. Any additional supplies (syringes, mixing vials, etc.) must be sourced separately by the research institution.

Sealed lyophilized peptide remains stable for approximately 2 years when stored properly. After reconstitution, the solution should be refrigerated and typically retains stability for several weeks depending on temperature and handling conditions.

No. Our products are supplied strictly for in vitro laboratory research. Because these compounds are not authorized for use on humans or animals outside approved research settings, we do not provide usage or dosing instructions.

All peptides are guaranteed to be at least 98% pure, verified by HPLC and mass spectrometry. A Certificate of Analysis is available for every batch.

Keep lyophilized peptides in a cool, dry place away from direct heat and light. Once reconstituted, refrigerate the solution to maintain stability and preserve peptide integrity.