Semax

CAS 80714-61-0 · Neuro Research

10 MG

$29.00

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⚠ RESEARCH USE ONLY

This product is sold strictly for in vitro laboratory research use only. Not for human or animal consumption, diagnostic use, or therapeutic application. Purchasers must be qualified researchers or authorized purchasers for a research institution.

CERTIFICATE OF ANALYSIS

Third party tested for: Purity · ID · Quantity

BATCH #202610071412 View All →

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Semax Overview

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) based on the ACTH(4-7) fragment of adrenocorticotropic hormone, with a C-terminal Pro-Gly-Pro tail that improves its stability.

In research models, Semax has been examined for its role in neuroprotection, expression of neurotrophins such as BDNF and NGF, cerebral ischemia, and cognitive-performance paradigms.

Reference: Dolotov O. V. et al. (2006), Brain Res, 1117(1), 54-60.

History

Semax was developed in the 1980s at the Institute of Molecular Genetics of the Russian Academy of Sciences. Researchers sought to retain the neurotrophic properties of the ACTH(4-10) fragment while removing its hormonal (corticotropic) activity, and the Pro-Gly-Pro extension was added to resist peptidase breakdown. It has since been studied extensively in preclinical models, with much of the literature originating in Russia.

Reference: Dmitrieva V. G. et al. (2010), Cell Mol Neurobiol, 30(1), 71-79.

Semax Structure

CAS #: 80714-61-0

Molecular Formula: C₃₇H₅₁N₉O₁₀S

Molecular Weight: 813.9 g/mol

PubChem CID: 9811102

Research Findings

Semax has been studied in cell culture and in rodent models of cerebral ischemia and cognition. Reported findings describe changes in neurotrophin and gene expression and effects on neuronal survival signaling.

Key Areas of Research:

Neuroprotection: Outcomes in preclinical models of focal cerebral ischemia
Neurotrophins: Upregulation of BDNF and NGF expression in brain tissue
Gene expression: Transcriptome changes in ischemia-related models
Cognition models: Learning and memory paradigms in rodents

These converging observations make Semax a widely used research tool for studying neurotrophin signaling and neuronal resilience.

References: Dolotov O. V. et al. (2006), Brain Res, 1117(1), 54-60.; Dmitrieva V. G. et al. (2010), Cell Mol Neurobiol, 30(1), 71-79.

References

Frequently Asked Questions

Everything you need to know about our products and processes.

Each vial contains the exact quantity listed on the label. A 10 mg vial contains 10 mg of lyophilized peptide. Research-grade purity supports accurate dosing for experimental protocols.

Peptides ship as lyophilized powder. Every order includes a complimentary vial of bacteriostatic water for reconstitution. Any additional supplies (syringes, mixing vials, etc.) must be sourced separately by the research institution.

Sealed lyophilized peptide remains stable for approximately 2 years when stored properly. After reconstitution, the solution should be refrigerated and typically retains stability for several weeks depending on temperature and handling conditions.

No. Our products are supplied strictly for in vitro laboratory research. Because these compounds are not authorized for use on humans or animals outside approved research settings, we do not provide usage or dosing instructions.

All peptides are guaranteed to be at least 98% pure, verified by HPLC and mass spectrometry. A Certificate of Analysis is available for every batch.

Keep lyophilized peptides in a cool, dry place away from direct heat and light. Once reconstituted, refrigerate the solution to maintain stability and preserve peptide integrity.